趙硯彬(Zhao Yanbin)

教授

電子郵件：zhaoyanbin@sjtu.edu.cn
辦公地點(diǎn)：環(huán)境樓615室

個(gè)人簡(jiǎn)歷

上海交通大學(xué)教授、博士生導(dǎo)師，環(huán)境科學(xué)與工程學(xué)院副院長(zhǎng)，高層次青年人才。國(guó)際SCI期刊Journal of Hazardous Materials專刊編委，Eco-Environment & Health青年編委，ACS ES&T Water雜志編委會(huì)委員。上海市毒理學(xué)會(huì)委員，中國(guó)環(huán)境誘變劑學(xué)會(huì)出生缺陷防治專業(yè)委員會(huì)委員。致力于污染物環(huán)境健康效應(yīng)研究。運(yùn)用分子生物學(xué)與分析化學(xué)、生物信息學(xué)與人工智能技術(shù)，圍繞新污染物環(huán)境健康風(fēng)險(xiǎn)識(shí)別和毒性效應(yīng)與機(jī)制開展系統(tǒng)深入研究工作。近年來主持國(guó)家自然科學(xué)基金、國(guó)家重點(diǎn)研發(fā)計(jì)劃、上海市科技行動(dòng)計(jì)劃等科研項(xiàng)目多項(xiàng)。在Environ. Sci. Technol.、Environ. Int.等環(huán)境領(lǐng)域及重要國(guó)際綜合類SCI期刊上發(fā)表論文60余篇，獲授權(quán)國(guó)家發(fā)明專利2項(xiàng)，參編中英文專著2部，瑞士FHNW生態(tài)環(huán)境研究所年度杰出論文獎(jiǎng)。

研究方向

研究領(lǐng)域：環(huán)境健康 (Environmental Health)，環(huán)境大數(shù)據(jù) (Big Data in Environment), 環(huán)境生物技術(shù) (Environmental Biotechnology)
主要研究方向：發(fā)育毒性效應(yīng)與機(jī)制 Developmental Toxicity in Early Life Stages
環(huán)境大數(shù)據(jù)與人工智能 Environmental Big Data and Artificial Intelligence
環(huán)境行為與人體暴露 Environmental Behavior and Human Exposures
環(huán)境生物技術(shù) Environmental Biotechnology
課題組鼓勵(lì)多學(xué)科交叉研究，歡迎對(duì)基因組學(xué)大數(shù)據(jù)分析與人工智能、環(huán)境化學(xué)、環(huán)境毒理學(xué)領(lǐng)域感興趣的同學(xué)加入。
Google Scholar: https://scholar.google.com/citations?hl=zh-CN&user=EfM4al4AAAAJ&view_op=list_works&sortby=pubdate

科研項(xiàng)目

國(guó)家自然科學(xué)基金面上項(xiàng)目：典型氟苯液晶TFPPC致斑馬魚胚胎類“海豹肢畸形”發(fā)育毒性機(jī)制研究，主持
國(guó)家自然科學(xué)基金高層次青年人才項(xiàng)目：環(huán)境激素的生殖和發(fā)育毒性，主持
國(guó)家自然科學(xué)基金面上項(xiàng)目：有機(jī)磷酸酯心血管毒性效應(yīng)識(shí)別與毒性作用機(jī)制研究，主持
國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目：典型塑料添加劑危害性篩查及預(yù)測(cè)關(guān)鍵技術(shù)，骨干參與
國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目：兒童常見發(fā)育行為性疾病的早期診斷與干預(yù)及預(yù)警體系建立，骨干參與
上海市科學(xué)技術(shù)委員會(huì)浦江人才計(jì)劃項(xiàng)目：典型環(huán)境皮質(zhì)激素倍他米松和氟氫可的松心血管毒性效應(yīng)及作用機(jī)理研究，主持
上海交通大學(xué)醫(yī)工交叉項(xiàng)目：逆轉(zhuǎn)白色念珠菌對(duì)佛康唑耐藥的新型抗真菌藥物篩選及機(jī)制研究，交大-負(fù)責(zé)人

榮譽(yù)獎(jiǎng)勵(lì)

2024年 上海交通大學(xué)年度教學(xué)成果獎(jiǎng)一等獎(jiǎng)（7/8）
2024年 環(huán)境科學(xué)與工程學(xué)院最受歡迎教師獎(jiǎng)
2023年 上海交通大學(xué)青年教師教學(xué)競(jìng)賽三等獎(jiǎng)
2023年 上海交通大學(xué)優(yōu)秀班主任
2022年 環(huán)境科學(xué)與工程學(xué)院青年教師教學(xué)競(jìng)賽二等獎(jiǎng)
2021年 環(huán)境科學(xué)與工程學(xué)院年度考核優(yōu)秀個(gè)人
2021年 國(guó)家優(yōu)秀青年科學(xué)基金獲得者
2019年 上海交通大學(xué)青年教師教學(xué)競(jìng)賽三等獎(jiǎng)
2019年 環(huán)境科學(xué)與工程學(xué)院青年教師教學(xué)競(jìng)賽二等獎(jiǎng)
2019年 上海市浦江人才計(jì)劃項(xiàng)目獲得者
2016年 瑞士FHNW生態(tài)環(huán)境研究所年度杰出論文獎(jiǎng)

代表性論著 (近五年)

1. An R, Wang J, Cao L, Yue X, Zheng S, Zhao Y. B.,* Dai J, Zhang K.* Environmental Risks of Thermal Insulation Manufacturing under Global Decarbonization: A Case Study of Organophosphate Esters Using Targeted and Nontargeted Analyses. Environ. Sci. Technol. 2025, 59 (48), 26157-26170.
2. Zuo S, Zhang K, Dai J, Fent K, Huang AY, Zhao Y. B.* Genetic Polymorphisms in Nuclear Receptors Drive Variations in Responses to Environmental Exposures. Environ. Sci. Technol. 2025, 59(37), 19733-19744.
3. Wang C, Gui W, Zhang K,* Cao L, An R, Zhou J, Li M, Chen X, Wang H, Dai J, Zhao Y. B.* Typical Thermochromic Dye Crystal Violet Lactone Acts as an Endocrine Disruptor: Nontargeted Screening, Prioritization, and In Vivo Experimental Verification. Environ. Sci. Technol. 2025, 59(26), 13227-13239.
4. Li H, Dong K, Zhao M, Li R, Shi C, Wang C, Wei Y, Li J, Chen L, Zhao Y. B.,* Li Y.* 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (F-53B) Induces Aging and Parkinson's Disease-like Disorders in C. elegans at Low Concentrations. Environ. Sci. Technol. 2025, 59(28), 14249-14257.
5. Chen J, Li B, Zuo S, Zhang K, Dai J, Chen L.,* Zhao Y. B.* Pattern Recognition-Driven Detection of Circadian-Disruptive Compounds from Gene Expressions: High-Throughput Screening and Experimental Verification. Environ. Sci. Technol. 2025, 59 (12), 5960-5972.
6. Zhang Z, Shi H, Zhang K,* An R, Wang C, Wang P, Chan SA, Song Y, Dai J, Zhao Y. B.* Transcriptome-Guided Characterization of the Environmental Toxicity of Metformin: Disruption of Energy Homeostasis and Inhibition of Embryonic Development of Zebrafish at Environmentally Relevant Concentrations. Environ. Sci. Technol. 2024, 58 (40), 17580-17591.
7. Shi H, Zhao Y. B.* Integration of Advanced Large Language Models into the Construction of Adverse Outcome Pathways: Opportunities and Challenges. Environ. Sci. Technol. 2024, 58 (35), 15355-15358.
8. Chen J, Wang C, Tu W, Zhang K, Fent K, Dai J, Hecker M, Giesy JP, Zhao Y. B.* AOP-Anchored Transcriptome Analysis Catalogue Accelerates the Discovery of Environmental Toxicants in Zebrafish. Environ. Sci. Technol. 2024, 58 (30), 13217-13225.
9. Zheng, S.; Wang, J.; Luo, K.; Gu, X.; Yuan, G.; Wei, M.; Yao, Y.; Zhao, Y. B.; Dai, J. Y.; Zhang K.* Comprehensive Characterization of Organic Light-Emitting Materials in Breast Milk by Target and Suspect Screening. Environ. Sci. Technol. 2024, 58 (11), 5103-5116.
10. Wang, C.; Li, M.; Gui, W.; Shi, H.; Wang, P.; Chen, J.; Fent, K.; Zhang, K.; Dai, J.; Li, X.; Zhao, Y. B.* Prednisolone Accelerates Embryonic Development of Zebrafish via Glucocorticoid Receptor Signaling at Low Concentrations. Environ. Sci. Technol. 2023 , 57 (42), 15794-15805.
11. Shi, H.; Li, M.; Meng, H.; Zheng, X.; Zhang, K.; Fent, K.; Dai, J.; Zhao, Y. B.* Reduced Transcriptome Analysis of Zebrafish Embryos Prioritizes Environmental Compounds with Adverse Cardiovascular Activities. Environ. Sci. Technol. 2023, 57 (12), 4959-4970.
12. Zuo, S. Q.; Meng, H. Y.; Liang, J. H.; Zhen, H. J.; Zhu, Y.; Zhao, Y. B.; Zhang, K.*; Dai, J. Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China. Environ. Sci. Technol. 2022, 56 (4), 2312-2322.
13. Wang, J.; Nan, J.; Li, M.; Yuan, G.; Zhao, Y. B.; Dai, J.; Zhang, K.* First evidence of contamination in aquatic organisms with organic light-emitting materials. Environ. Sci. Technol. Lett. 2022, 9, 739-746.
14. Shen, J.; Shi, H. C.; Zhao, Y. B.; Fent, K.; Zhang, K.* Large-Scale Transcriptional Profiling of Molecular Perturbations Reveals Cell Line Specific Responses and Implications for Environmental Screening. Environ. Sci. Technol. 2021, 55 (22), 15266-15275.
15. Zhang, K.; Liang, J.; Brun, N. R.; Zhao, Y. B.*; Werdich, A. A. Rapid zebrafish behavioral profiling assay accelerates the identification of environmental neurodevelopmental toxicants. Environ. Sci. Technol. 2021, 55 (3), 1919-1929.
16. Zhao, Y. B.; Liang, J.; Meng, H.; Yin, Y.; Zhen, H.; Zheng, X.; Shi, H.; Wu, X.; Zu, Y.; Wang, B.; Fan, L.; Zhang, K.* Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish (Danio rerio). Environ. Sci. Technol. 2021, 55 (2), 1155-1166.
17. Zheng, X. H.; Zhang, K.; Zhao, Y. B.*; Fent, K.* Environmental Chemicals Affect Circadian Rhythms: an Underexplored Effect Influencing Health and Fitness in Animals and Humans. Environ. Int. 2021, 106159.
18. Liang, J. H.; Meng, H. Y.; Zhou, J.; Yin, Y.; Zhen, H. J.; Zhao, Y. B.*; Zhang, K.* Simultaneous Occurrence of Psychotropic Pharmaceuticals in Surface Water of the Megacity Shanghai and Implication for Their Ecotoxicological Risks. ACS ES&T Water 2021, 1 (4), 825-836.
19. Zhao, Y. B.; Zhang, K.*; Xu, X. T.; Shen, H. Z.*; Zhu, X.; Zhang, Y. X.; Hu, Y. T.; Shen, G. F. Substantial changes in nitrogen dioxide and ozone after excluding meteorological impacts during the COVID-19 outbreak in mainland China. Environ. Sci. Technol. Lett. 2020, 7, 402-408.