研究方向

研究領(lǐng)域： 環(huán)境分析監(jiān)測(cè)，環(huán)境污染物行為，環(huán)境健康

現(xiàn)階段主要研究方向：

• 環(huán)境中新污染物的分析監(jiān)測(cè)及其來源和環(huán)境行為解析
• 環(huán)境中未知污染污染物的非靶標(biāo)篩查和鑒定
• 環(huán)境污染物質(zhì)對(duì)健康，特別是對(duì)神經(jīng)發(fā)育的影響

個(gè)人簡(jiǎn)歷

• 2003-2007 北京大學(xué)，城市與環(huán)境學(xué)院 環(huán)境科學(xué)，理學(xué)學(xué)士
• 2007-2012 北京大學(xué)，城市與環(huán)境學(xué)院 環(huán)境地理學(xué)，理學(xué)博士
• 2012-2015 加拿大阿爾伯塔大學(xué)，實(shí)驗(yàn)醫(yī)學(xué)與病理學(xué)系，博士后
• 2015-2016 瑞士西北應(yīng)用科技大學(xué)，生態(tài)環(huán)境研究所，博士后
• 2017-2018 美國(guó)哈佛大學(xué)醫(yī)學(xué)院，高級(jí)研究助理

研究成果

高層次青年人才，主要致力于環(huán)境新污染物的環(huán)境行為和生物學(xué)效應(yīng)研究。利用氣相/超高效液相質(zhì)譜聯(lián)用檢測(cè)技術(shù)結(jié)合體外微粒體暴露，微生物降解，PBPK模型模擬，野外樣品采集分析等方式對(duì)環(huán)境污染物質(zhì)的來源降解、不同結(jié)構(gòu)食物網(wǎng)生物富集差異、藥代行為學(xué)特征及其生態(tài)毒理學(xué)效應(yīng)開展了系統(tǒng)研究工作。同時(shí)，利用超高分辨質(zhì)譜非靶向檢測(cè)技術(shù)結(jié)合生物模擬和魚體暴露等方法開發(fā)了對(duì)環(huán)境中復(fù)合有機(jī)污染物毒性和生物富集性評(píng)估的新方法體系，并將其成功應(yīng)用于油砂廢水等復(fù)雜場(chǎng)景中優(yōu)先控制污染物名單篩查。以上研究成果共發(fā)表SCI論文40余篇，其中第一/通訊作者SCI論文20余篇 (Environ. Sci. Technol. 10篇，Environ. Sci. Technol. Lett. 2篇，Environ. Int. 1篇)。先后主持參與上海市浦江人才計(jì)劃項(xiàng)目、國(guó)家自然科學(xué)基金面上項(xiàng)目、創(chuàng)新群體項(xiàng)目等科研項(xiàng)目。

代表性論著

1. Zuo, S. Q.; Meng, H. Y.; Liang, J. H.; Zhen, H. J.; Zhu, Y.; Zhao, Y. B.; Zhang, K.*; Dai, J. Residues of Cardiovascular and Lipid-Lowering Drugs Pose a Risk to the Aquatic Ecosystem despite a High Wastewater Treatment Ratio in the Megacity Shanghai, China. Environ. Sci. Technol. 2022, 56 (4), 2312-2322.
2. Shen, J.; Shi, H. C.; Zhao, Y. B.; Fent, K.; Zhang, K*. Large-Scale Transcriptional Profiling of Molecular Perturbations Reveals Cell Line Specific Responses and Implications for Environmental Screening. Environ. Sci. Technol. 2021, 55 (22), 15266-15275.
3. Zhang, K.; Liang, J. H.; Brun, N. R.; Zhao, Y. B.*; Werdich, A. A. Rapid Zebrafish Behavioral Profiling Assay Accelerates the Identification of Environmental Neurodevelopmental Toxicants. Environ. Sci. Technol. 2021, 55 (3):1919-1929.
4. Zhao, Y.; Liang, J.; Meng, H.; Yin, Y.; Zhen, H.; Zheng, X.; Shi, H.; Wu, X.; Zu, Y.; Wang, B.; Fan, L.; Zhang, K*. Rare Earth Elements Lanthanum and Praseodymium Adversely Affect Neural and Cardiovascular Development in Zebrafish. Environ. Sci. Technol. 2021, 55 (2):1155-1166.
5. Zhao, Y. B.; Zhang, K.*; Xu, X. T.; Shen, H. Z.*; Zhu, X.; Zhang, Y. X.; Hu, Y. T.; Shen, G. F. Substantial changes in nitrogen dioxide and ozone after excluding meteorological impacts during the COVID-19 outbreak in mainland China. Environ. Sci. Technol. Lett. 2020, 7, 402-408. (Highlight, High Cited)
6. Zhang, K.; Zhao, Y. B.* Reduced Zebrafish Transcriptome Atlas toward Understanding the Environmental Neurotoxicants. Environ. Sci. Technol. 2018, 52 (12), 7120-7130.
7. Zhang, K.; Zhao, Y.; Fent, K. Occurrence and ecotoxicological effects of free, conjugated and halogenated steroids of 17α-hydroxypregnanolone and pregnanediol in Swiss wastewater and surface water. Environ. Sci. Technol. 2017, 51 (11), 6498–6506.
8. Zhang, K.; Wiseman, S. B.; Giesy, J. P.; Martin, J. W. Bioconcentration of Dissolved Organic Compounds from Oil Sands Process-Affected Water by Medaka (Oryzias latipes): Importance of Partitioning to Phospholipids. Environ. Sci. Technol. 2016, 50 (12), 6574–6582.
9. Zhang, K.; Pereira, A. S.; Martin, J. W. Estimates of Octanol–Water Partitioning for Thousands of Dissolved Organic Species in Oil Sands Process-Affected Water. Environ. Sci. Technol. 2015, 49 (14), 8907-8913.
10. Zhang, K.; Wan, Y.; Jones, P. D.; Wiseman, S.; Giesy, J. P.; Hu, J. Y. Occurrences and Fates of Hydroxylated Polybrominated Diphenyl Ethers in Marine Sediments in Relation to Trophodynamics. Environ. Sci. Technol. 2012, 46 (4), 2148?2155.