戴家銀(Dai Jiayin)
特聘教授
電子郵件：daijy65@sjtu.edu.cn
研究方向
1. 新型污染物的高通量檢測與識別
2. 新型污染物的人體暴露特征與健康效應(yīng)
3. 新型污染物的毒性效應(yīng)及分子機(jī)制
4. 基于毒性規(guī)律指導(dǎo)化學(xué)品綠色替代與合成
研究領(lǐng)域包括環(huán)境分析、環(huán)境健康與毒理學(xué)，鼓勵(lì)多學(xué)科交叉研究，歡迎具有環(huán)境科學(xué)、分子生物學(xué)、組學(xué)與生物信息學(xué)、分析化學(xué)等專業(yè)背景的同學(xué)參加本科生科研，攻讀碩士、博士學(xué)位。
個(gè)人簡歷
1996年－1999年 南京大學(xué)環(huán)境學(xué)院，獲博士學(xué)位
1999年－2000年 同濟(jì)大學(xué)環(huán)境科學(xué)與工程學(xué)院，博士后
2000年－2001年，美國德克薩斯州立大學(xué)加爾韋斯頓醫(yī)學(xué)分校，博士后
2001年－2005年，美國康奈爾大學(xué)醫(yī)學(xué)院，生物化學(xué)系，博士后
2005年－2020年，中國科學(xué)院動(dòng)物研究所，中國科學(xué)院動(dòng)物生態(tài)與保護(hù)生物學(xué)重點(diǎn)實(shí)驗(yàn)室，主任，研究員
2020年－至今，上海交通大學(xué)環(huán)境科學(xué)與工程學(xué)院，特聘教授
入選國家高層次人才計(jì)劃，國際期刊Chemical Research in Toxicology 和 Environmental Pollution 副主編，連續(xù)入選愛思唯爾中國高被引學(xué)者。任中國毒理學(xué)會環(huán)境與生態(tài)毒理學(xué)專業(yè)委員會 常務(wù)委員（第一~三屆）；中國環(huán)境學(xué)會環(huán)境風(fēng)險(xiǎn)專業(yè)委員會 委員（2012年1月-至今）；中國環(huán)境科學(xué)學(xué)會持久性有機(jī)污染物專業(yè)委員會 委員（2012年1月-至今）；中國毒理學(xué)會計(jì)算毒理專業(yè)委員會委員（第一屆-至今）；中華預(yù)防醫(yī)學(xué)會環(huán)境衛(wèi)生分會常務(wù)委員（第八屆）。中國科學(xué)院城市環(huán)境研究所城市環(huán)境健康重點(diǎn)實(shí)驗(yàn)室 學(xué)術(shù)委員會委員（2013年1月-至今）；安徽省濕地生態(tài)保護(hù)與修復(fù)重點(diǎn)實(shí)驗(yàn)室 學(xué)術(shù)委員會委員（2018年-至今）。
主持國家自然科學(xué)基金重點(diǎn)項(xiàng)目、重大國際合作項(xiàng)目、973項(xiàng)目和國家重點(diǎn)研發(fā)計(jì)劃、中科院知識創(chuàng)新工程重要方向性項(xiàng)目、中科院戰(zhàn)略先導(dǎo)B項(xiàng)目課題等19項(xiàng)。2004年以來在Cell, Nature Communication, Environmental Health Perspectives, Environmental Sciences & Technology等重要SCI刊物發(fā)表論文210余篇，他引11000余次，H因子53。培養(yǎng)的研究生多人次先后獲中國科學(xué)院優(yōu)秀博士論文、國家獎(jiǎng)學(xué)金、中國科學(xué)院院長優(yōu)秀獎(jiǎng)、朱李月華獎(jiǎng)學(xué)金等。
科研成果
代表性科研項(xiàng)目（10項(xiàng)）
1. 國家自然科學(xué)基金委重點(diǎn)項(xiàng)目（21737004），基于系統(tǒng)性毒性研究指導(dǎo)全氟烷基化合物替代品設(shè)計(jì)與綠色合成，2018/01-2022/12，300萬，主持
2. 國家重點(diǎn)研發(fā)計(jì)劃生殖專項(xiàng)，課題二（2018YFC1004202），男性不育的環(huán)境-基因交互作用研究，2018/12-2021/12，188萬（987萬），參加
3 國家自然科學(xué)基金委面上項(xiàng)目（21876173），全氟烷基化合物替代品影響斑馬魚魚鰾發(fā)育的分子機(jī)制研究，2019/01-2022/12，66萬，主持
4. 國家重點(diǎn)研發(fā)計(jì)劃食品專項(xiàng)，課題五（2017YFC1600205），食品中典型持久性有機(jī)污染物健康危害與毒性機(jī)制，2017/01-2021/12，300萬，課題負(fù)責(zé)人
5. 國家自然科學(xué)基金委面上項(xiàng)目（21377128），全氟類化合物與人類肝臟型脂肪酸結(jié)合蛋白的相互作用及毒性機(jī)制研究，2014/01-2017/12，88萬，主持
6. 國家自然科學(xué)基金國際(地區(qū))合作與交流項(xiàng)目（31320103915），野生動(dòng)物體內(nèi)全氟烷基化合物的來源、存在狀態(tài)及毒性機(jī)制研究，2014/1-2018/12，274萬，主持
7. 中科院先導(dǎo)B專項(xiàng)，項(xiàng)目四課題二子課題二（XDB14040202），典型污染物引發(fā)機(jī)體糖和脂肪代謝紊亂的機(jī)制，2014/07-2019/06，421萬，子課題負(fù)責(zé)人
8. 國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃），課題四（2013CB945204），血脂紊亂影響精子發(fā)生的生物標(biāo)記物的鑒定和臨床干預(yù)，2013/01-2017/08，556萬，課題負(fù)責(zé)人
9. 國家自然科學(xué)基金委重點(diǎn)項(xiàng)目（20837004），典型全氟有機(jī)污染物的水環(huán)境過程及生態(tài)毒理機(jī)制研究，2009/01-2012/12，200萬元，主持
近五年代表性論文（30篇）
(1) Yao Jingzhi, Pan Yitao, Sheng Nan, Su Zhaoben, Guo Yong, Wang Jianshe, Dai, Jiayin(*), Novel perfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs): Occurrence and association with serum biochemical parameters in residents living near a fluorochemical plant in China, Environmental Science & Technology, 2020, 54 (21): 13389-13398
(2) Wang Jinghua, Pan Yitao, Wei Xiaofei, Dai, Jiayin(*), Temporal Trends in Prenatal Exposure (1998-2018) to Emerging and Legacy Per- and Polyfluoroalkyl Substances (PFASs) in Cord Plasma from the Beijing Cord Blood Bank, China, Environmental Science & Technology, 2020, 54 (20): 12850-12859
(3) Cui Qianqian, Pan Yitao, Wang Jinghua, Liu Hongxiu, Yao Bing, Dai, Jiayin(*), Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones, Environmental Pollution, 2020, 266 (2): 115330
(4) Liu Hongxiu(#), Pan Yitao(#), Jin Shuna; Sun Xiaojie, Jiang Yangqian, Wang Yuyan, Ghassabian Akhgar, Li Yuanyuan, Xia Wei, Cui Qianqian, Zhang Bin, Zhou Aifen, Dai Jiyin(*), Xu Shunqing(*). Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China. Journal of hazardous materials, 2020, 124378
(5) Liu Hongxiu(#), Pan Yitao(#), Jin Shuna, Li Yuanyuan, Zhao Liuqing, Sun Xiaojie, Cui Qianqian, Zhang bin, Zheng Tongzhang, Xia Wei, Zhou Aifen, Campana Anna Maria, Dai Jiyin(*), Xu Shunqing(*). Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns, Environment International, 2020, 140: 105636
(6) Pan, Yitao, Wang, Jinghua, Yeung, L. W. Y., Wei, Si, Dai, Jiayin(*), Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues, Trends in Analytical Chemistry, 2020, 124: 115481
(7) Wang, Jinxing(#), Shi Guohui(#), Yao Jingzhi, Sheng Nan, Cui, Ruina, Su Zhaoben, Guo, Yong, Dai, Jiayin(*), Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption, Environment International, 2020, 134: 105317
(8) Pan, Yitao, Cui, Qianqian, Wang, Jinghua, Sheng Nan, Jing, Jun, Yao, Bing(*), Dai, Jiayin(*), Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality, Environmental Health Perspectives, 2019, 127 (12): 127005
(9) Cui, Qianqian(#), Shi, Fanglei(#), Pan, Yitao, Zhang, Hongxia, Dai, Jiayin(*), Per- and polyfluoroalkyl substances (PFASs) in the blood of two colobine monkey species from China: Occurrence and exposure pathways, Science of the Total Environment, 2019, 674: 524-531
(10) Guo, Hua, Wang, Jinghua, Yao, Jingzhi, Sun, Sujie, Sheng, Nan, Zhang, Xiaowen, Guo, Xuejiang, Guo, Yong, Sun, Yan, Dai, Jiayin(*), Comparative hepatotoxicity of novel PFOA alternatives (perfluoropolyether carboxylic acids) on Male Mice, Environmental Science & Technology, 2019, 53 (7): 3929-3937
(11) Shi, Guohui, Cui, Qianqian, Wang, Jinxing, Guo, Hua, Pan, Yitao, Sheng, Nan, Guo, Yong, Dai, Jiayin(*), Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring, Environmental Pollution, 2019, 249: 550-559
(12) Shi, Guohui, Wang, Jinxing, Guo, Hua, Sheng, Nan, Cui, Qianqian, Pan, Yitao, Guo, Yong, Sun, Yan, Dai, Jiayin(*), Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish, Science of the Total Environment, 2019, 665: 855-863
(13) Sun, Sujie, Guo, Hua, Wang, Jianshe(*), Dai, Jiayin, Hepatotoxicity of perfluorooctanoic acid and two emerging alternatives based on a 3D spheroid model, Environmental Pollution, 2019, 246: 955-962
(14) Cui, Ruina, Li, Chenyang, Wang, Jianshe(*), Dai, Jiayin, Induction of hepatic miR-34a by perfluorooctanoic acid regulates metabolism-related genes in mice, Environmental Pollution, 2019, 244: 270-278
(15) Wang, Jinghua(#), Pan, Yitao(#), Cui, Qianqian, Yao, Bing, Wang, Jianshe(*), Dai, Jiayin, Penetration of PFASs across the Blood Cerebrospinal Fluid Barrier and Its Determinants in Humans, Environmental Science & Technology, 2018, 52 (22): 13553-13561
(16) Sun, Sujie, Wang, Jianshe(*), Lu, Yin, Dai, Jiayin, Corticosteroid-Binding Globulin, Induced in Testicular Leydig Cells by Perfluorooctanoic Acid, Promotes Steroid Hormone Synthesis, Archives of Toxicology, 2018, 92 (6): 2013-2025
(17) Zhou, Xiujuan, Wang, Jianshe(*), Sheng, Nan, Cui, Ruina, Deng, Yiqun, Dai, Jiayin, Subchronic Reproductive Effects of 6:2 Chlorinated Polyfluorinated Ether Sulfonate (6:2 Cl-Pfaes), an Alternative to PFOS, on Adult Male Mice, Journal of Hazardous Materials, 2018, 358: 256-264
(18) Zhang, Hongxia, Zhou, Xiujuan, Sheng, Nan, Cui, Ruina, Cui, Qianqian, Guo, Hua, Guo, Yong, Sun, Yan, Dai, Jiayin*, Subchronic hepatotoxicity effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), a novel perfluorooctanesulfonate (PFOS) alternative, on adult male mice, Environmental Science & Technology, 2018, 52 (21): 12809-12818
(19) Shi, Guohui, Guo, Hua, Sheng, Nan, Cui, Qianqian, Pan, Yitao, Wang, Jinxing, Guo, Yong, Dai, Jiayin*, Two-generational reproductive toxicity assessment of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B, a novel alternative to perfluorooctane sulfonate) in Zebrafish, Environmental Pollution, 2018, 243: 1517-1527
(20) Cui, Qianqian, Pan, Yitao, Zhang, Hongxia, Sheng, Nan, Dai, Jiayin(*), Elevated concentrations of perfluorohexanesulfonate and other per and polyfluoroalkyl substances in Baiyangdian Lake (China): source characterization and exposure assessment, Environmental Pollution, 2018, 241: 684-691
(21) Cui, Qianqian(#), Pan, Yitao(#), Zhang, Hongxia, Sheng, Nan, Wang, Jianshe, Guo, Yong, Dai, Jiayin(*), Occurrence and tissue distribution of novel ferfluoroether carboxylic and sulfonic acids and legacy per/polyfluoroalkyl substances in Black-Spotted Frog (Pelophylax Nigromaculatus), Environmental Science & Technology, 2018, 52 (3): 982-990 （ESI數(shù)據(jù)庫（highly cited papers）收錄）
(22) Pan, Yitao(#), Zhang, Hongxia(#), Cui, Qianqian, Sheng, Nan, Yeung, Leo W. Y., Sun, Yan, Guo, Yong, Dai, Jiayin(*), Worldwide distribution of novel perfluoroether carboxylic and sulfonic acids in surface water, Environmental Science & Technology, 2018, 52 (14): 7621-7629 （ESI數(shù)據(jù)庫（highly cited papers）收錄）
(23) Sheng, Nan, Cui, Ruina, Wang, Jinghua, Guo, Yong, Wang, Jianshe, Dai, Jiayin(*), Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell Line and their binding capacity to human liver fatty acid binding protein, Archives of Toxicology, 2018, 92 (1): 359-369 （ESI數(shù)據(jù)庫（highly cited papers）收錄）
(24) Sheng, Nan, Pan, Yitao, Guo, Yong, Sun, Yan, Dai, Jiayin(*), Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), a novel perfluorooctanoic acid (PFOA) alternative, on mice, Environmental Science & Technology, 2018, 52 (14): 8005-8015
(25) Shi, Guohui, Xie, Yu, Guo, Yong, Dai, Jiayin(*), 6:2 Fluorotelomer sulfonamide alkylbetaine (6:2 ftab), a novel perfluorooctane sulfonate alternative, induced developmental toxicity in Zebrafish embryos, Aquatic Toxicology, 2018, 195: 24-32
(26) Pan Yitao, Zhang Hongxia, Cui Qianqian, Sheng Nan, Yeung Leo W. Y., Guo Yong, Sun Yan, Dai, Jiayin(*).First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern, Environmental Science & Technology, 2017, 51(17): 9553-9560
(27) Shi Guohui, Cui Qianqian, Pan Yitao, Sheng Nan, Guo Yong, Dai, Jiayin(*).6:2 fluorotelomer carboxylic acid (6:2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis, Aquatic Toxicology, 2017, 190: 53-61
(28) Shi, Guohui, Cui, Qianqian, Pan, Yitao, Sheng, Nan, Sun, Sujie, Guo, Yong, Dai, Jiayin(*), 6:2 Chlorinated polyfluorinated ether sulfonate, a PFOS alternative, induces embryotoxicity and disrupts cardiac development in zebrafish embryos, Aquatic Toxicology, 2017, 185: 67-75 （ESI數(shù)據(jù)庫（highly cited papers）收錄）
(29) Yan, Shengmin, Zhang, Hongxia, Guo, Xuejiang, Wang, Jianshe, Dai, Jiayin(*), High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver, Archives of Toxicology, 2017, 91 (1): 247-258
(30) Pan, Yitao(#), Zhu, Yingshuang(#), Zheng, Tongzhang, Cui, Qianqian, Buka, Stephen L, Zhang, Bin, Guo, Yong, Xia, Wei, Yeung, Leo W Y, Li, Yuanyuan, Zhou, Aifen, Qiu, Lin, Liu, Hongxiu, Jiang, Minmin, Wu, Chuansha, Xu, Shunqing(*), Dai, Jiayin(*), Novel chlorinated polyfluorinated ether sulfonates and legacy per-/polyfluoroalkyl substances: placental transfer and relationship with serum albumin and glomerular filtration rate, Environmental Science & Technology, 2017, 51 (1): 634-644 （ESI數(shù)據(jù)庫（highly cited papers）收錄）